IDENTIFICATION OF SUMOYLATION SITES IN CCDC6, THE FIRST IDENTIFIED RET PARTNER GENE IN PAPILLARY THYROID CARCINOMA, UNCOVERS A MODE OF REGULATING CCDC6 FUNCTION ON CREB1 TRANSCRIPTIONAL ACTIVITY.

CCDC6 was originally identified in chimeric genes as caused by chromosomal translocation involving the RET protooncogene in some thyroid tumors.Recognised as a 65 kDa pro-apoptotic phosphoprotein, CCDC6 has been enrolled as an ATM substrate that contribute to protect genome integrity by modulating PP4c activity in response to genotoxic stress.Recen

BackgroundToxoplasmosis, having the significant consequences affecting mortality and quality of life, is still prevalent in various places throughout the world.The major gap in surveillance for Toxoplasma gondii infection among high-risk population, slaughterhouse workers, is an obstacle for the effective policies formulation to reduce the burden o

A method for the production of paper with high strength and grease resistance was developed.Filter paper was impregnated by an aqueous solution of zinc chloride at a fixed temperature for several seconds.Swelling and partial dissolution of the cellulose fibers resulted in strong and compact paper.Various influencing factors were investigated in an

The author examines the religious and political course of the Ottoman Sultan Abdul Hamid II (1876-1909), aimed at strengthening the unity of the Ottoman state and society based on the principles of Islam, and the implementation of this strategy in the Syrian provinces of the Ottoman Empire.The research is based on reports of contemporaries, as well

Heart disease 7-Piece Sectional with Audio Console is the main cause of death which can be diagnosed using an electrocardiogram.This study aims to classify heart defects using the Fuzzy C Means technique.The advantage of using Fuzzy C Means is that it is unsupervised and can reach a convergent cluster center under certain conditions.It is a cluster